Scanning The Genome
نویسندگان
چکیده
منابع مشابه
Predicting CpG Islands and DNA Methlation in the Cow Genome Using DNA Microarray Meta-Analysis and Genome Wide Scanning
DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...
متن کاملScanning the human genome at kilobase resolution.
Normal genome variation and pathogenic genome alteration frequently affect small regions in the genome. Identifying those genomic changes remains a technical challenge. We report here the development of the DGS (Ditag Genome Scanning) technique for high-resolution analysis of genome structure. The basic features of DGS include (1) use of high-frequent restriction enzymes to fractionate the geno...
متن کاملGenome-based peptide fingerprint scanning.
We have implemented a method that identifies the genomic origins of sample proteins by scanning their peptide-mass fingerprint against the theoretical translation and proteolytic digest of an entire genome. Unlike previously reported techniques, this method requires no predefined ORF or protein annotations. Fixed-size windows along the genome sequence are scored by an equation accounting for th...
متن کاملGenome scanning tests for comparing amino acid sequences between groups.
Consider a placebo-controlled preventive HIV vaccine efficacy trial. An HIV amino acid sequence is measured from each volunteer who acquires HIV, and these sequences are aligned together with the reference HIV sequence represented in the vaccine. We develop genome scanning methods to identify positions at which the amino acids in infected vaccine recipient sequences either (A) are more divergen...
متن کاملKnowledge-Based Analysis of Genome-Wide SNP Scanning Data
Many million dollar-scale genome-wide association (GWA) studies are currently underway for identifying genetic elements involved in complex disorders. However, prevailing GWA data analysis methods are focusing on the association of individual SNP alleles with a complex disease, although multiple alleles are involved by definition. Available data suggest few SNP alleles can pass the genomewide m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Medicine
سال: 2007
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0107-27